Gough DA, Kumosa LS, Routh TL, Lin JT, Lucisano JY (2010) Function of an implanted tissue glucose sensor for more than 1 year in animals. Sci Transl Med 2(42):42ra53 Hawley JA, Lessard SJ (2008) Exercise training-induced improvements in insulin action. Acta physiol 192(1):127–135

The monkeys housed in our animal facility were fed twice per day. The postprandial increase in blood glucose was very minor with a few small fluctuations after morning feeding and was more obvious with one main peak after afternoon feeding (Fig. 4a). This pattern of food intake in NHPs differs from humans. Generally speaking, humans complete their meals in a certain period of time (most likely less than 1 h). Blood glucose increase after a meal is more obvious and relatively predictable in humans. However, most of our housed monkeys might not complete their meals in a relatively short period of time, especially after morning feeding. The monkeys could eat and play with their food for quite a while, which initiated those small fluctuations of blood glucose after morning feeding (Fig. 4a). Postprandial increase in blood glucose was more obvious with one main peak after afternoon feeding. This peak potentially indicated the change of the housed monkey behavior. They were smart to intake enough food before 7 pm as the access became difficult after light off. This postprandial blood glucose pattern in housed NHPs also resulted from the advantage of the implantable telemetry device which did not affect animal normal behavior. To validate the reliability of the telemetry method, blood glucose levels were measured at different time points and with or without various challenges 1 week after device implantation. During the study, 187 blood glucose parameters were collected by both telemetry and glucometer methods in normoglycemic ( n = 3) and diabetic ( n = 2) monkeys. The blood glucose levels measured by the telemetry method were highly correlated with those read by the glucometer (Fig. 1d, Y = 0.9804 x + 3.2753, R² = 0.9466, p< 0.001), which suggests that the telemetry method with the implantable HD-XG device is reliable for continuous blood glucose monitoring. Blood glucose fluctuations during daily activities The Dark Magic Inflatable Thrusting Machine looks like it could be a simple inflatable lounger with really good leg support–that is until you notice the remote control that controls motor thrusting toys for a realistic experience while you’re going solo. The overnight-fasted monkeys were restrained in the monkey chair. After stabilization of their blood glucose levels based on the HD-XG glucose signals, angiotensin II at 2 μg/kg was administered intravenously by bolus injection. Blood glucose level gradually increased and reached the peak within 10 min after angiotensin II injection in both normoglycemic (L02) and diabetic (J04) monkeys (Fig. 6b). The hyperglycemic response to angiotensin II slowly waned and lately even went lower than the pre-angiotensin II level in the diabetic animal (J04, Fig. 6b). It is interesting that intravenous bolus injection of acetylcholine at 1 μg/kg did not alter blood glucose levels in both normoglycemic and diabetic monkeys implanted with HD-XG telemetry devices (data not shown). Glucose tolerance test and other tests in NHPs with implanted HD-XG deviceIt also has a hole on top of it where you can insert a vibe or other toy and you can use it as a mountable chair or stand it up on its side flat against the headboard. Islam MS (2013) Animal models of diabetic neuropathy: progress since 1960s. J Diabetes Res. doi: 10.1155/2013/149452

The experimental animals (normoglycemia, n = 3 and diabetes, n = 2) were fasted overnight (approximately 16 h) and restrained in the monkey chair. When blood glucose stabilized for around 30 min via observation of the HD-XG glucose signals, the glucose solution (1.75 g/kg = 5 mL/kg of 35% dextrose) was given to the animal via oral gavage. Blood glucose was measured by glucometer (StatStrip Xpress meter) immediately before and at 15, 30, 60, 90, 120, and 180 min after glucose administration. Meanwhile, blood glucose levels were monitored by the implanted HD-XG device throughout the entire test. The results were plotted and correlated with each other very well (Fig. 7, OGTT). ITT Stout PJ, Racchini JR, Hilgers ME (2004) A novel approach to mitigating the physiological lag between blood and interstitial fluid glucose measurements. Diabetes Technol Ther 6(5):635–644 That’s where inflatable toys like Dark Magic come in. It inflates into this lounger (a foot pump is provided to blow it up) which holds the thrusting motor exactly where you need it. There are bolsters built in to prop your legs up and there is space on either side of these bolsters for your legs if you want to flip over on your knees. Ensuring that the chair restraint process is as fully refined as possible will reduce any stress and discomfort to a minimum, facilitating good performance from the monkey and good scientific data. Workshop funding Brijesh M (2015) Somogyi effect in a patient of type 2 diabetes mellitus. J Diabetes Metab 6:493 doi: 10.4172/2155-61561000493With the addition of short lengths of chain, you can even create the 3D shapes shown in the images above by attaching the board to itself. Your flat bondage surface becomes a spanking chair or supportive wedge to bend a submissive over for all sorts of play. One thing to consider is its size. It’s has a roughly two feet by three feet footprint and this is not the type of thing that folds flat when not in use. You have to have space to dedicate to it, but if you’re building a home dungeon, it certainly has an intimidating look to it. ITT is used to examine if the body produces enough ACTH (adreno-cortico-trophic hormone) and growth hormone under stress. The ‘stress’ in this test was to lower blood sugar (hypoglycemia) by injected insulin under very controlled conditions. ACTH stimulates the adrenal glands to make cortisol which is a steroid hormone and has many functions, including balancing the effect of insulin in regulating blood glucose levels. Five animals (normoglycemia, n = 3 and diabetes, n = 2) were fasted overnight (16 h) and restrained in the monkey chair. When blood glucose levels stabilized for around 30 min via observation of the HD-XG glucose signals, the insulin solution (0.15 U/kg = 0.15 mL/kg of insulin injection) was given to each animal via S.C. injection [ 5]. Blood glucose levels were measured by the glucometer method (StatStrip Xpress meter) immediately before and at 30, 60, 90, and 120 min after insulin administration (Fig. 7, ITT). Meanwhile, blood glucose levels were monitored and recorded by implanted HD-XG devices. The results were plotted against the time and were correlated very well between the telemetry results and the glucometer readings. GGI It comes with a realistic TPE toy (not silicone so could be better but if you’re not sharing it, that’s not the end of the world). The toy has five inches of insertable length and a diameter of 1.5 inches. And if you’re not quite sure what that means, EdenFantasys has one of my favorite features of all time where you can view the item in Real Size by adjusting the size of the item to fit a scaled image held up to your screen like a US dollar and credit card.

Wang X, Hansen BC, Shi D, Fang Y, Du F, Wang B, Chen YM, Gregoire FM, Wang YX (2013) Quantification of beta-cell insulin secretory function using a graded glucose infusion with C-peptide deconvolution in dysmetabolic, and diabetic cynomolgus monkeys. Diabetol Metab Syndr 5(1):40 Chronically dysfunctional carbohydrate metabolism results in diabetes due to a relative deficiency of insulin. Various animal models have been used in research for understanding diabetes and discovering novel therapies for the disease [ 1– 4]. Nonhuman primates (NHPs) can naturally develop to Type 2 diabetes mellitus (T2DM) in a way similar to the progression and onset of T2DM in humans. Dysmetabolic NHPs have thus been used for diabetes and obesity research in many studies [ 5– 8]. NHP models also play an important role in screening novel compounds for regulation of food intake, blood glucose, and/or body weight. The data from NHP models can result in discovery and validation of new mechanism or therapeutic strategy and target of dysmetabolic diseases [ 9, 10]. Wisniewski N, Reichert M (2000) Methods for reducing biosensor membrane biofouling. Colloids Surf B Biointerfaces 18(3–4):197–219

Who Actually Buys Sex Furniture? 

It says the chair includes an adapter so you can attach your favorite toys but I’m not seeing images of what that looks like. Wang B, Sun G, Liu Y, Qiao J, Ye W, Wang H, Wang X, Chng K, Qiao W, Wang Y et al (2016) Dysglycemia and dyslipidemia models in nonhuman primates: part II. Model of naturally occurring or experimental obesity. J Diabetes Metab 6:641. doi: 10.4172/2155-6156.1000641 Helton KL, Ratner BD, Wisniewski NA (2011) Biomechanics of the sensor-tissue interface-effects of motion, pressure, and design on sensor performance and foreign body response-part II: examples and application. Journal of diabetes science technology 5(3):647–656