During the course of my second postdoctoral position, I established a novel method for the isolation of pure populations of unactivated murine peripheral blood neutrophils. Singh, A.K., and P.R. Singh. 2016. Development of a tractor operated sugarcane cutter planter for mechanization of sugarcane planting in deep furrows. Sugar Tech. doi: 10.1007/S12355-016-0471-9.

Editorial board member for Scientific Reports (2018-), Pharmacology Research and Perspectives (2016-) and Journal of Inflammation (2016-2019). My first postdoctoral position was at the NHLI, Imperial College, London in 1997 working with Professors Tim Williams and Ian Sabroe. I have recently been awarded a number of BHF funded Grants to investigate these aspects of neutrophils function, one of which is to carry out cutting-edge intravital imaging of the carotid in Professor Marc van Zandvoort’s group at the University of Maastricht. Burnett A, Gomez I, De Leon D, Ariaans M, Progias P, Kammerer R, Velasco G, Marron M, Hellewell P & Ridger V (2017) Angiopoietin-1 enhances neutrophil chemotaxis in vitro and migration in vivo through interaction with CD18 and release of CCL4. Scientific Reports, 7. View this article in WRRO Doan, V., Y. Chen, and B. Irvine. 2005a. Effect of oat stubble height on the performance of no-till seeder openers. Canadian Biosystems Engineering 47: 237–244.Sai Agro Two Furrow Surry Ridger: It requires a tractor of 30 – 40 HP like Massey Ferguson 1035 DI to operate. It comes with 3 blades. Burnett A, Hellewell P & Ridger V (2012) REGULATION OF MONOCYTE-ENDOTHELIAL CELL INTERACTIONS BY NEUTROPHIL-DERIVED MICROPARTICLES. HEART, Vol. 98 (pp A3-A4) Ridger VC, Hellewell PG & Norman KE (2002) sLe(x) can mediate rolling on P-selectin only in combination with L-selectin. FASEB J, 16(5), A1213-A1213. Abbitt KB, Cotter MJ, Ridger VC, Crossman DC, Hellewell PG & Norman KE (2009) Antibody ligation of murine Ly-6G induces neutropenia, blood flow cessation, and death via complement-dependent and independent mechanisms.. J Leukoc Biol, 85(1), 55-63. Miotla JM, Ridger VC & Hellewell PG (2001) Dominant role of L- and P-selectin in mediating CXC chemokine-induced neutrophil migration in vivo.. Br J Pharmacol, 133(4), 550-556.

Neutrophil-derived microvesicle-induced blood brain barrier dysfunction and white matter lesion formation in the ageing brain. Alzheimer's Research UK Studentship (2016-2019).Nolan SL, Norman KE, Hellewell PG & Ridger VC (2004) PC16 NITRIC OXIDE INHIBITION ENHANCES MURINE NEUTROPHIL MIGRATION IN VITRO. Microcirculation, 11(6), 544-544. Godwin, R.J. 2007. A review of the effect of implement geometry on soil failure and implement forces. Soil Tillage Research 97: 331–340. Gomez I, Ward B, Evans P, Hellewell P & Ridger V (2015) Abstract 558: Neutrophils-derived-microvesicle Could Play a Role in the Early Stage of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 35(Supp 1) (pp A558-A558)

Greenacre S, Ridger V, Wilsoncroft P & Brain SD (1997) Peroxynitrite: a mediator of increased microvascular permeability?. Clin Exp Pharmacol Physiol, 24(11), 880-882. Mamman, E., and J.O. Ohu. 1998. The effect of tractor traffic on air permeability and millet production in a sandy loam soil in Nigeria. Ife Journal of Technology 8(1): 1–7. Ridger VC & Hellewell PG (2000) A role for CD29 in CD18-independent neutrophil in mouse lungs. FASEB J, 14(4), A10-A10. Ward B, Gomez I, Willis J, Woods R, Parry S, Hulston C, Evans P & Ridger V (2017) Neutrophil microvesicles are increased by high-fat over-feeding and enhance monocyte recruitment to endothelial cells under disturbed flow. Atherosclerosis, Vol. 263 (pp e123-e124) Dow R & Ridger V (2021) Neutrophil microvesicles and their role in disease. The International Journal of Biochemistry & Cell Biology, 141.Ridger VC & Brain SD (1996) Peroxynitrite induces plasma extravasation in rat dorsal skin. BRIT J PHARMACOL, 119, P56-P56.

Winter is well and truly on it's way.The leaves are falling and you can feel the bite of the wind in Read More > With winter still in full force you might not think it time to sort out the garden and with none of Read More > I currently have collaborations with Dr Helen Philippou and Dr Robert Ariens at the University of Leeds investigating in vivo thrombus formation in the femoral vein. I also work closely with Dr Julie Simpson in SITraN investigating the role of neutrophil microvesicles in neuroinflammation, studies funded by Alzheimer’s Research. Current projects: Prepare for springAfter terribly cold conditions, February is a month for optimism, there are some signs Read More >

Type

The project I undertook was investigating the inhibition of VLA-4 in asthmatic responses in a rabbit model and this, together with my PhD project carried out under the supervision of Professor Susan Brain, ignited my interest in inflammation. Ridger V, Krams R, Carpi A & Evans PC (2008) Hemodynamic parameters regulating vascular inflammation and atherosclerosis: a brief update.. Biomed Pharmacother, 62(8), 536-540. Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J & Francis SE (2015) Neutrophil Elastase promotes Interleukin-1β secretion from Human Coronary Endothelium. Journal of Biological Chemistry, 290, 24067-24078. View this article in WRRO Mahmoud M, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis S , Van der Heiden K et al (2017) Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Scientific Reports, 7. View this article in WRRO Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ , Ariaans M et al (2022) JAG1-NOTCH4 mechanosensing drives atherosclerosis. Science Advances, 8(35).