Edifier MR4 Powered Studio Monitor 2.0 Speakers 42 Watts (Black)

£69.68
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Edifier MR4 Powered Studio Monitor 2.0 Speakers 42 Watts (Black)

Edifier MR4 Powered Studio Monitor 2.0 Speakers 42 Watts (Black)

RRP: £139.36
Price: £69.68
£69.68 FREE Shipping

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I voted "great" instead of "fine", as I think that there's tremendous value here if you don't mind medium volume levels and a little EQ. NATURAL SOUND: A 1-inch silk diaphragm unit with special coating ensures smooth and natural treble, and the specially designed integrated front panel combined with the cone brings clearer diffusion of the high frequency. Taking down the resonances around 615 Hz took out some of the stuffiness of the upper bass and provided more clarity.

It is possible that we have underestimated the probability of loss of MR3 in the patients who achieved only sMR3 because this group may contain two distinct sub-populations: those who are destined to achieve sMR4 with longer follow up (and therefore have a better outcome) and those who do not have the biological potential to achieve deeper responses.Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons. Probabilities of loss of responses after achieving sustained molecular response (MR)-3 (sMR3) and sMR4.

The paddles are of proven design to give efficient mix action; they are produced to ensure a perfectly balanced shape that eliminates paddle wobble MR4 paddles are the most popular design for a wide range of bagged materials, plaster, cements, resins, coatings, wet and pourable mixes. Some of the patients who lost MR3 were on a reduced dose of their TKI and our observations are supported by the findings of the DESTINY study, 23 in which approximately 30% of patients in sMR3 who reduced their TKI dose by 50% subsequently lost MR3. A) Probability of loss of MR3 and MR4 after the first year in MR4 (vertical line indicates time of sMR4, i.Enabling multi-directional mode change on-the-go provides exceptional flexibility and movement around obstacles and in narrow working environments.

Three of these patients experienced progression to accelerated phase, of whom two died subsequently in blast phase and one achieved MR4 on a different TKI. BCR-ABL mRNA levels at and after the time of a complete cytogenetic response (CCR) predict the duration of CCR in imatinib mesylate-treated patients with CML.Achieving a major molecular response at the time of a complete cytogenetic response (CCgR) predicts a better duration of CCgR in imatinib-treated chronic myeloid leukemia patients. In summary, we have shown that risk of loss of MR3 is negligible in patients who have achieved sMR4, particularly in those who remain on standard dose TKI who have not demonstrated prior resistance and who are known to be compliant. The impact of the various levels of molecular response on patient outcome has been studied by others. In contrast, lack of compliance might be a contributing factor to the failure of patients in sMR3 to gain deeper responses.

Power handling is rated at 21W RMS (per) and the quoted frequency response is 60Hz-20kHz with an SNR of ≥85dB(A) and an THD+N(%) of ≤0. As you could tell from the (in-room) preview in the intro, there is a dip in the lower treble frequencies. Baseline characteristics were compared using the Mann-Whitney test for continuous variables, and Fisher Exact test for categorical variables. MR4 maintained for at least one year represents a secure response threshold for patients with CML, after which no MR3 loss occurs if certain conditions are satisfied (standard TKI dose, full compliance, and lack of previous TKI resistance). We interrogated our single center database to determine if we could identify a level of MR that is highly unlikely to be lost provided the patient remains on treatment, a molecular threshold that would render frequent molecular monitoring unnecessary.Moreover, the time to sMR3 was longer in patients in whom this was the best response than in those who achieved sMR4. Five were known to be non-compliant with therapy, five were on lower doses of TKI, and ten had previously received TKI doses greater than standard doses for resistance ( Figure 2). MR4 sustained for 12 months is associated with stable deep molecular responses in chronic myeloid leukemia. Good for if you have say a PS5 on one screen and a PC outputting to the other with some YouTube or something. If you want a decent entry point for getting better audio from your PC then these are a definitely worth picking up.



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