Plate diffusion test. Antibacterial activity against E. coli DH5α demonstrated on seeded agar plates by different antibiotics is indicated by clear zones where growth inhibition has occurred. Freshly grown E. coli cells (OD 600 = 0.2, 300 µL) were embedded in 20 mL warm agar in a Petri dish (diameter 9 cm). Afterwards, holes (diameter 0.6 cm) were punched out and filled with 40 µL of antibiotic solution at the mM concentrations indicated. Pictures were taken after 24 h of incubation in the presence of the antibiotics. ( A) kanamycin; ( B) allicin; and ( C) ampicillin. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Allicin: The Beneficial Compound that Makes Garlic So Healthy De Greef D, Barton EM, Sandberg EN, et al. Anticancer potential of garlic and its bioactive constituents: a systematic and comprehensive review. Semin Cancer Biol. 2021;73:219-264. doi:10.1016/j.semcancer.2020.11.020

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Lawson L, Hunsaker S. Allicin bioavailability and bioequivalence from garlic supplements and garlic foods. Nutrients. 2018;10(7):812. Bat-Chen and co-workers, for instance, showed that Nrf2 is involved in allicin-induced apoptosis [ 106]. This reveals the “Janus face” of Nrf2 [ 107]: While Nrf2 is mostly described as an anti-apoptotic factor regulating the expression of anti-apoptotic proteins of the Bcl-2 family like Bcl-2 and Bcl-xL [ 108, 109], Nrf2 also seems to have a pro-apoptotic function under certain circumstances ( ibid.). Also the ERK1/2 map kinases were shown to be influenced by allicin in immune cells; these kinases are also important for apoptosis induction by allicin [ 103, 110]. Choo S, Chin VK, Wong EH, et al. Review: antimicrobial properties of allicin used alone or in combination with other medications. Folia Microbiol (Praha). 2020;65(3):451-465. doi:10.1007/s12223-020-00786-5 It’s one reason why eating garlic is linked to widespread health benefits, like cardiovascular health, better cognition, resistance to infection and other anti-aging effects,Not only does it offer protection to garlic plants themselves, but allicin benefits humans in a variety of ways too. For example, studies have found that whether from eating garlic or taking allicin supplements, allicin can help treat infections, support cardiovascular function and more. What Is Allicin? Allicinis the compound that forms from crushed or chopped garlic. Itis highly regarded for it's ability to reduce inflammation and offer antioxidantbenefits.In the manufacturing process, a special flood reaction system using only water is able to produce large quantities of stabilised allicin. The liquid is then carefully dried, under controlled conditions, to maintain its potency. This unique process has for the first time allowed its creators to capture garlic's active component in a form that can be used by your body. Is allicin max an antibiotic? Glutathione biosynthesis and function: ( A) Cysteine and glutamate are enzymatically linked to γ-glutamylcysteine via the action of glutamate cysteine ligase (GCL). The next step in synthesis is the formation of glutathione itself from cysteine and γ-glutamylcysteine via glutathione synthetase (GS). ( B) Glutathione can be oxidized to glutathione dimers (GSSG) and thereby serves to buffer oxidants within the cell. A shift in the equilibrium from GSH towards a higher proportion of GSSG may promote the glutathiolation of free cysteines on protein surfaces, thus shielding these cysteine residues during oxidative stress conditions from over-oxidation. Illustration was redrawn from [ 116]. El-Saber Batiha G, Magdy Beshbishy A, G Wasef L, et al. Chemical Constituents and Pharmacological Activities of Garlic ( Allium sativum L.): A Review. Nutrients. 2020;12(3):872. Published 2020 Mar 24. doi:10.3390/nu12030872 A 2014 study published in the journal Molecules states, “allicin can inhibit the proliferation of both bacteria and fungi, or kill cells outright, including antibiotic-resistant strains like methicillin-resistant Staphylococcus aureus (MRSA).”

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Isolation and testing of the organosulfur compounds from garlic for antimicrobial activity was carried out in the 1940s [ 9]. Neither DADS, directly formed by the decomposition of allicin, nor the diallylpolysulfanes showed any remarkable antimicrobial activity, unless used in very high concentrations. Koch and Lawson [ 5] determined the minimal concentration of organosulfur compounds found in crushed garlic needed to inhibit the growth of Escherichia coli and Staphylococcus aureus. According to their results, approximately 35× more DADS (6.15 mM) was needed to inhibit the growth of these two bacteria compared to allicin (0.17 mM). Haghi A, Azimi H, Rahimi R. A Comprehensive Review on Pharmacotherapeutics of Three Phytochemicals, Curcumin, Quercetin, and Allicin, in the Treatment of Gastric Cancer. J Gastrointest Cancer. 2017;48(4):314-320. doi:10.1007/s12029-017-9997-7Ried K. Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: an updated meta-analysis and review. J Nutr. 2016;146(2):389S-396S. doi:10.3945/jn.114.202192 Allicin Max formed on the 11th August 1999, on the day of the solar eclipse, here in Great Britain. However founding member and managing director, Norman Bennett, had long been devoting his time and research into the powerful properties of garlic since the late 1980's. As a frequent user of garlic supplements, Norman was fully aware of garlic's active components and their beneficial effects on health and wellness but a publication by Paul Simons, entitled 'Garlic: The Powerful Panacea', helped him to establish one of the active principles, which is still used today. From this ‘lightbulb’ moment, Allicin Max was born, and so was the world's first fully stabilised, allicin food supplement. What is Allicin and how is it made? Beside this agriculture-orientated application, fungal infections of humans and animals are a focus of interest [ 57]. Thus, it was claimed that allicin might be the basis of a strategy to treat aspergillosis in the lung, since allicin is highly volatile and thus can be delivered to the lung by inspiration [ 58]. Allicin can also easily be applied topically to fungal infections of the skin and hence attempts were made to use allicin in the therapy of Candida-infections. Interestingly, allicin’s activity was comparable to the frequently used antimycotic agent fluconazole [ 55]. There is an emerging interest in understanding the molecular basis of allicin’s fungicidal properties. Pure allicin supplements or extracts are not sold commercially, but rather garlic supplements are. These contain a larger variety of compounds.

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While a number of studies have found that garlic pills can have cholesterol-lowering properties, others have not found such effects. Allicin Max is dietaryfoodsupplement that uses the power of Garlic to protect your Immune System. Itis the only brand on the market that provides a product with stabilised allicin.Today, these unique, stabilised allicin based products are used by health practitioners and consumers throughout the UK and exported to over forty countries worldwide. How did the brand start? Safety considerations: Insufficient data in children and pregnancy, but it may impact a nursing child's digestion Because it has a broad range of biological activities and breaks down to form other organosulfur compounds, allicin uses include: Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Our team aims to be not only thorough with its research, but also objective and unbiased.

Heating garlic has been shown to reduce its antioxidant, antibacterial and vascular protective effects, since it changes the chemical composition of sulfur compounds. Some studies have found that during one minute in the microwave or 45 minutes in the oven, a significant amount has been lost, including almost all anticancer activity. Higher doses (2,400–7,200 milligrams of garlic extract) may interact with medications including Warfarin, however moderate doses are safe to combine with most drugs. Ashraf R, Khan RA, Ashraf I, Qureshi AA. Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Pak J Pharm Sci. 2013;26(5):859-63. It’s believed that the way garlic is prepared, and how allicin and other compounds are extracted, may explain this. S-allylcysteine on the other hand is bioavailable and has the ability to lower cholesterol, since it acts as an antioxidant and anti-inflammatory agent. It is no wonder that hospitals are now buying allicin to put on feeding tubes, catheters, etc. as a means of preventing infection! 6